This ukiyo-e is from the series ‘Thirty-six Views of Mount Fuji’ 富嶽三十六景 by Hokusai (1760-1849).
The series was made in the early 1830s. This is picture No. 43 with the title ‘Dawn at Isawa in the Kai Province’ (甲州伊沢暁—kôshû isawa no akatsuki). The Kai province is located in today’s Yamanashi prefecture of Japan. Here you see typical historical Japanese houses with thatched roofs. On the middle road groups of merchants are transporting commercial goods, some on horses. They are carrying items like rice, food and various products in wooden boxes or in bundles.